CORE-Well Adrenal

Non-returnable

Core-Well Adrenal

• Clinical Education Handout

• Purpose: Stress regulation, cortisol balance, nervous system support, and resilience to physical and emotional stress

• Clinical Rationale

Chronic stress disrupts the hypothalamic–pituitary–adrenal (HPA) axis, leading to cortisol imbalance, fatigue, mood changes, poor sleep, and impaired resilience. Core-Well Adrenal is designed to support healthy stress adaptation by modulating cortisol response, calming the nervous system, and protecting against stress-induced physiologic damage.

This formula combines adaptogens, calming botanicals, and amino acid support to address both mental and physical stress pathways.

Key Ingredients & Clinical Reasoning

Ashwagandha (Withania somnifera)

Clinical role:

• Adaptogen that helps normalize cortisol levels

• Supports HPA axis regulation

• Improves stress resilience and anxiety symptoms

Why it is included: Ashwagandha has strong evidence for reducing stress-related cortisol elevation and improving symptoms of anxiety, fatigue, and poor sleep. It supports long-term stress adaptation rather than short-term stimulation.

Clinical pearls:

• Helpful for patients with chronic stress, burnout, or insomnia

• May improve sleep quality and daytime energy balance

L-Theanine

Clinical role:

• Promotes alpha brain wave activity

• Calms the nervous system without sedation

• Supports focus and relaxation

Why it is included: L-Theanine reduces sympathetic nervous system overactivity while maintaining alertness. It is particularly helpful for stress-related anxiety, racing thoughts, and sleep-onset difficulty.

Clinical pearls:

• Useful for patients who feel “wired but tired”

• Can reduce stress-induced increases in heart rate and blood pressure

Chinese Skullcap Root (Scutellaria baicalensis)

Clinical role:

• Anxiolytic and calming botanical

• Anti-inflammatory and neuroprotective

• Supports GABAergic activity

Why it is included: Chinese Skullcap helps calm the central nervous system while also addressing inflammation linked to chronic stress. It is particularly beneficial for stress-related irritability and sleep disturbances.

Clinical pearls:

• Helpful for patients with anxiety and poor stress tolerance

• Supports brain health during prolonged stress exposure

Rhodiola Rosea

Clinical role:

• An adaptogen that improves stress tolerance

• Reduces mental and physical fatigue

• Supports cognitive performance under stress

Why it is included: Rhodiola enhances resilience to stress by improving energy production and reducing stress-induced fatigue without overstimulation. It supports endurance and mental clarity during periods of high demand.

Clinical pearls:

• Ideal for patients experiencing stress-related exhaustion

• May improve focus, mood, and performance

Clinical Benefits Summary

• Supports healthy cortisol regulation

• Improves stress resilience and emotional balance

• Promotes calm focus without sedation

• Supports sleep quality and recovery

• Protects against stress-related fatigue and burnout

Who May Benefit

• Individuals with chronic stress or burnout

• Patients with sleep disturbances related to stress

• Those experiencing anxiety, irritability, or mental fatigue

• High-demand professionals, caregivers, or parents

• Patients with signs of HPA axis dysregulation

Clinical Use Notes

• Intended for daily stress support, not acute anxiety treatment

• Effects are cumulative with consistent use

• May be combined with lifestyle interventions such as sleep hygiene, hydration, and stress management practices

Important Disclaimer

This product is intended for nutritional support only and is not intended to diagnose, treat, cure, or prevent disease. Patients who are pregnant, breastfeeding, or taking medications should consult a healthcare professional before use.